A person addicted to some type of speed whose favorite hobbies include taking things apart beyond recognition, sitting by the backdoor with a large knife, 'dieting', watching American Idol, and staying up for up to 2 weeks strait. They can some times be dangerous, but are usually a lot of fun.
Yea, that fucking tweeker was about to stab me when I walked through the door, but then she realized who I was! After I watched American Idol with her she gave me her TV to go across town and get her some more crystal. Yea, she's been looking really skinny...
by Cali February 11, 2004
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A person who is addicted to crystal meth and undergoes great changes in personality and appearance. The biggest populations are in small towns and rural areas. The drug is incredibly cheap and easy to manufacture, so no matter where you live there is probably at least 3-4 residents in your neighborhood making it in their garage.

There are a few very easy ways to spot a tweeker.

1. Very skinny, with especially gaunt faces
2. Complete disregard for appearance. They will have dirty clothes, be unshaven, messy hair, no makeup.

3. Appear to be much older than they actually are.
4. Brown teeth, often with many missing.

5. They have red sores all over themselves, this is from picking at their skin while high.
6. They are generally very paranoid and confused.

You can see them anywhere, in a small town it's not uncommon to see a dozen in the course of a day. Generally avoid them and don't give them the impression that you have anything of value. If you see them in a retail store, they are almost 100% guaranteed to steal something.

It's a sad transition, and almost always their journey ends in prison or death.
Drive to the oldest, shadiest area of your town and observe the people walking around, you will spot some tweekers almost immediately.
by Maximillian Van Der Mann January 23, 2011
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The homeless, meth addict, usually skinny, smelly, who is riding a 10,000 racing mountain bike, dressed in rags, malnourished, at three oclock in the morning through the streets of sunnyslope, (phx az)with a 10 foot antique brass lamp over there shoulder on their way to the (meth)dope mans house to score another $20 bag, if you watch him long enough you will most likely see him look over his shoulder to see if "they" are close behind, you will likely see him stop at each and every dumpster that looks like it might have anything at all in it.
phx cop to glendale cop: anything new tonight?... (tweeker rides by on sidewalk causing officer to spill his coffee) damm tweekers! watch where you going or ill arrest your ass for ....glendale cop in response....."you mean you actually bother to arrest them? me and the boys find it so much quicker just to stop em, confiscate their drugs and let them go."
by nobody in phx June 19, 2009
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Those who indulge themselves with Methamphetamine until they become very paranoid and develop a serious case of body tremor.
eg. People who ask for money on a daily basis; people who consistently and rapidly scratch themselves. "Hey check those tweekers arguing with the cops, the one on the left looks all messed up."

eg. Tyrone Biggums from the "Chappelle Show"; Jake Mazursky from "Alpha Dog"; Every character in the movie Spun; That chick from Full House, in real life.
by Romero Diaz June 22, 2008
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Or spelled as tweaker, refers to someone who does meth, or cocaine.

Could also refer to abusing Adderall, or Dex, or similar drugs prescribed to treat ADHD. Because the ingredients are the same, Adderall is just a really really low dosage of it. Abusing get's you the same high, which is tweeking.
person 1:"Man what's your plans for the party tonight?"
person 2:"I plan on tweeking (getting high)on Adderall."
person 1:"Dude I knew you were a tweeker!!"
tweaker meth cocaine drugs party high
by midnightrise January 22, 2016
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