as others have stated: something has angered, upset, annoyed, aroused you
this is more of a side note on origin - I suspect the phrase was a spontaneous misquote of a line from the Weezer song "Say It Ain't So" ("...flip on the telly/ wrestle with Jimmy...")
man, that pic was disgusting.
yeah, that one rustled my jimmies
by kingprout1 July 31, 2015
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A term used in many different occasions when strong emotional needs are met. These emotions can range from sexual emotions to hateful emotions.
"Dude, she's so hot!"
"Yeah, she's really rustles my Jimmies."

"I was so angry, my Jimmies were rustled."

"She looks like she'd rustle your Jimmies."

"I got a good Jimmy rustling the other day."
by DylanGification August 27, 2011
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Repositioning sexual organs. For males, repositioning of the penis and testicles. For females, repositioning of the breasts.
by Skewesy October 20, 2013
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Another name for the game commonly known as "Hacky Sack".
"Come on mate! Get out the jimmy and we can start rustling!"

"Nice Jimmy Rustling there man!"
by HacktheSack May 28, 2012
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To plays with other male's genitalia
Whiterunguardwasbanned: "I'm just Rustling Some Jimmies."
by The_One_Above_All March 23, 2014
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jimmies – feelings / thoughts / ego
rustled – hurt / disturbed
unrustled – peaceful / calm

As per Know Your Meme, the expression originated from 4chan in late 2010, and is used by trolls to "convey feelings of discontent or discomfort in response to someone else’s post in imageboards and discussion forums".

The expression is an alternate form of "u mad bro?".
 
Victim: What the heck is your problem!?
Troll: Are your jimmies rustled?
Victim: ...What is this I don't even
Troll: *trollface*
by AgentRev June 17, 2012
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