To get belligerently drunk, to the point of blacking out and making choices you may regret
Anyone want to go get knuckled up at Applebee’s with me?
by TroopRespecter8 July 31, 2020
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The Act Of Whupping Someone's Ass!
BITCH All In My FACE We Bout 2 KNUCKLE UP In Did Bitch!!!
by MS. BOUNCE DAT AZZ July 12, 2006
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Guy 1: Did you see Stacey?

Guy 2: Yeah, total nipple slip! I'm totally going to knuckle up to that later
by leobaby1 November 18, 2011
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When two men choose to engage in mutual masturbation, implementing a "thumb war" grip and jerking themselves off simultaneously, locked at the knuckles.
Since he had a girlfriend, the young man decided to knuckle up with a buddy.
by DaXymbiont February 7, 2018
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