Slang for good friend or person you have known a while and bonded with ( Mano - male ) ( mana - female ) originated from the Spanish slang of hermano (brother) someone you are close to. Popular between 2 people that originate from seperate countries. I.e Britain and Spain
Hey, Mano!

Hey!
by ENG.DICT July 8, 2012
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23:11 <Manos> The last time I had pussy, it was awesome.
23:12 <willyg> yea
23:12 <Manos> This was YESTERDAY.
23:12 <willyg> it always is
23:12 <electronarcosis> cool
23:12 <Manos> And it was with 3 different women.
by mancharmer June 30, 2009
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odd, weird, out of the norm, creepy, mysterious, outlandish, ridiculous, and unusual; something seen as being in "the hands of fate." As made popular by MST3K.
"The other day, on a whim, my friends and I decided to kill a goat. We used a rock and it took eight tries. It sounded fun at first, but turned out to be manos."

by Thel200ster March 18, 2007
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If your name is Manos you’re either greek or your parents hate you. You’re definitely straight but you’re single 90% of the year and you’re chill asf. Most of y’all are shy af and have awesome music taste but you have an addiction to smth. You’re hot asf too
by Gang boi 1140 September 7, 2021
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actual v annoying sometimes. but is even worse when drunk. ok thats all. #sometimeswannakill
Person: ugh do u know manoe?
Other person: Oh ya i wanna kill that wvss bitch
person: Shes even worse when drunk
by mikehawk5781 November 1, 2019
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An expression used to show deep love, usually used for cute & adorable people. Frequently used by love-birds to express how they feel towards each other.
You're so adorable, can i call you my mano?
by Chullbulla November 23, 2013
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