The sudden onset of fucktardery amongst your FIFA team when you go three-nil down.

Symptoms include: The inability to pass to anyone, inability to tackle, sudden urges to set up the opposition for sitters and in bad cases, the complete loss of the ability to retain possession.
"How have you just scored with Stuart Downing?"

"You were 3-0 down, mate. There's no way your defenders could tackle a player of Stuart Downing's capability once Three-Nil Down Syndrome had kicked in".
by SERGATRON vs. FernanGOAL May 22, 2012
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Kind of like a brain fart, but much more severe. This usually happens in a discord call with your closest friends because of course it does.
Friend: Have you seen Mike anywhere?

You: No I haven't seen hyimom.

Friend: Hyimom?

You: Oh my god I have Post traumatic Down Syndrome
by VBSBazooka September 2, 2020
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The disorder in which a person's Down syndrome is so severe that his face is completely rotated out of proportion. More severe cases can affect muscle girth, especially in the forearms. This renders the victim's forearms indistingiushable from pencils. One's speech may also become unamusing and trite.
Chris Max, what's up with your face?
Max BABABABAABaabaaba!!!
Chris O, you must have Upside Down Syndrome, which renders yours forearms indistingiushable from pencils and your speech unwitty. My bad.
by R. Areaux February 16, 2009
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The disorder in which a person's Down syndrome is so severe that his face is completely rotated out of proportion. More severe cases can affect muscle girth, especially in the forearms. This renders the victim's forearms indistingiushable from pencils. One's speech may also become unamusing and trite.
Chris Max, what's up with your face?
Max BABABABAABaabaaba!!!
Chris O, you must have Upside Down Syndrome, which renders yours forearms indistingiushable from pencils and your speech unwitty. My bad.
by R. Areaux February 16, 2009
Get the Upside Down Syndrome mug.
The disorder in which a person's Down syndrome is so severe that his face is completely rotated out of proportion. More severe cases can affect muscle girth, especially in the forearms. This renders the victim's forearms indistingiushable from pencils. One's speech may also become unamusing and trite.
Chris Max, what's up with your face?
Max BABABABAABaabaaba!!!
Chris O, you must have Upside Down Syndrome, which renders yours forearms indistingiushable from pencils and your speech unwitty. My bad.
by R. Areaux February 16, 2009
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It's not a regularly used word in some cases. Generally to sum it up this type of down syndrome is way different. If you have class 1 it means that you are on the levels beyond stupid. You can suffer from eating Tide Pods, chalk, or key caps from your keyboard. On other lines you could be shoving screwdrivers up your ass or knives and twisting them.
Teacher: HEY! YOU! Get over here! No fireworks in school!
Retard: AAAAAAWWWW! *Shoves firecracker up ass and ignites it.*

Teacher: Well he did have Class 1 Down Syndrome.
by ratchetedboi12 February 26, 2017
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Noun: Down Syndrome received by having sexual intercourse with a retard who appears to be suffering from Down Syndrome whether or not he actually does suffer from Down Syndrome.

Usually it's just a faggot who thinks he's hot shit.
"Lindsay" Lohan caught Sexually Transmitted Down Syndrome (STDS) from having sex with that one douche Matthew.
by Landon Smithismith June 11, 2008
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