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setting up 

having a party
Friend 1: "Hey, are you setting up tonight?"
Friend 2: "I thought the set up was at your house."
setting up by FTD2016 September 4, 2016

setting up a new network 

When your friend makes up an excuse to skip game night but is actually at home practicing shibari with their partner.
Man 1: Yo bro! You doing Family Game Night?
Man 2: Sorry Homeslice, setting up a new network tonight.

setting up shop 

The act of preparing oneself for a session of sex with oneself (jerking off).
I forgot my backpack and when I ran back in to my apartment I caught my roommate setting up shop.
setting up shop by jeff74033 April 14, 2008

just setting up my twttr 

The very first tweet written on Twitter.
Kyle: Hey, do you know what the first tweet on Twitter was?
Chris: just setting up my twttr
Kyle: Okay.

setting yourself up 

John:This is so hard, that's what she said.
Brian:Dude, you're setting yourself up.

settin up shop

to be the first,to allow other people into the same field
yo lazy ass aint do shit, while im out settin up shop
settin up shop by Adum May 19, 2006