Basically something that is very large or huge
Most often used by potheads to describe their over stuffed joints
Did you see that stupid ass humvee it was a fucking mule only a fucktard would drive something like that!

Troy rolled Brian a fucking mule of a joint lastnight and i helped him smoke it.
by Les Crapp October 1, 2007
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A variant of the popular card game "pass the ace." In this version, when you lose the last of your three bets, you have the option to buy one extra turn (fuck the mule), usually for twice the price of one of the normal bets.
Dammit! I lost my last stack. That's a big pot out there. I'm gonna fuck the mule.
by henry73 August 23, 2005
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