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ay Gurl you tryna do up?

yo man this gurl last night was tryna do me up low key.

yo these gurls tryna run a train and do up.
Do Up by DAKHANFLICT July 15, 2011
1. inject a drug, especially heroin
2. to kill someone
3. going over
do up by VAKI5 August 20, 2003

do it up 

Jim: I'm tired, I might go lie down.
Dani: do it up.
do it up by duhani February 20, 2009

Let’s do it up 

“Let’s do it”, is super vague and may have negative connotations. Therefore, “let’s do it up” is used as a phrase to prelude to a situation that will only result in a positive uplifting outcome.
Can’t wait to go clubbing tonight. Let’s do it up boys!
Big game today but let’s not let the pressure get to us. Let’s do it up!

What up do 

A greeting used amongst people in urban setting. It can be used in several ways. It can express freindship,anger or a question. Used extensively in the upper east of the midwest; mainly Detroit.
(to a group of people) What up do!? (retrun answer) What up do!!