A pronouncement of the termination of a relationship by either one of the two parties involved in said relationship or an outside, objective party.
You: "Things were going so well. I called her twice a day, e-mailed and IM'ed her every five minutes, and gave up all my friends to hang out with her just to show her how much I cared. I honestly don't know what happened."
Vicfan: "It's over."