1 definition by msbuttersworth

Top Definition
Mad Lesbian Syndrome: An identified medical condition in which signs of crankiness, up-tight attitude and utter prude-like bitchiness are commonly displayed on a regular basis around pretty much everyone
Laura: “Dude, Becca straight up denied my back-yard bbq invite for Dan’s birthday and sent me a message later that said she had more important things to do. What the hell, man?”
Dave: “Sounds like a bad case of MLS. Whatever. Her loss!”
by msbuttersworth August 11, 2011
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