Any mental task, lesson, game, puzzle, complicated book or other mentally difficult thing that is fascinating but becomes hard to comprehend after awhile, sending one into a confused state known as brain melt.
"I've tried to read 'A Brief History of Time' but after about the first few pages I just go into brain melt."
Sugar or sugar-filled foods, especially when consumed in excessive amounts that is unhealthy. "Twinkage" is a mix of the words "tweaker" and "twinkie", implying sugar as a drug, especially as used by children.
"Good god, let's get out of here, the kids have been eating twinkage all day and soon the screaming will begin."