A drug user who gains pride and purpose from taking a wide assortment of drugs, especially the endless variations of tryptamines and phenethylamines. Drug Twinkies generally view their drug use as profound mental exploration, and will harp on comparing the different psychonautic possibilities of various drugs.
"I just want acid, not any of that obscure drug twinkie crap."
Originally refers to those homosexuals who are so ineffably heteronormative that they act like typical breeders, even though they are a slave to the cock (or the vag). Its use has expanded as a insult for those who differ from the mainstream in an interesting or awesome way, but can't own it or face it.
"If you really like cheesy disco music, fine, but admit it or you'll be another straight fag.