1 definition by RuggerLez09
A disease afflicting lesbians. A lesbian acquires penis disease when she has sex with a guy and then tries to get with a girl again, normally resulting in rejection.
Heather: "Hey Amanda, you busy later tonight?"
Amanda: "Haven't you been sleeping with Alex? No thanks, I don't want to catch your penis disease."
Amanda: "Haven't you been sleeping with Alex? No thanks, I don't want to catch your penis disease."
by RuggerLez09 June 7, 2011