When your friends that are normally online to help you chat your way through your work day decide to go on vacation or get jobs where they can't be online anymore. Similar to empty nest, you feel very alone!
Chrisy: I'm going to New York for the week.
Kim: Oh i got a new job. I start today, so I wont be online anymore during work hours.
Jen: Screw you guys, I'm going to have a serious case of Empty Net Syndrome. :-(