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1 definition by Ishy

 
1.
An extremely offensive term for a transsexual man or woman, or any of the transgendered community.

On the same level as "nigger", and "cunt" for most people, though, like "dyke", some of the transgendered community are trying to reclaim the word, without much success.
"So your girlfriend's a tranny?" "... Please don't say that... She's a woman, just like you are."
by Ishy March 23, 2006