HPOA simply put means Hot piece of ass; it can be used against any sex and it is an acronym to fool the person it is being said to.
Sometimes used as HOPA... cause it sounds better
1 "Hey, did you see a link where a girl quits by erase board via email cause of various reasons including being called a HPOA"
2 "A HPOA? what's that?"
1 "check urbandictionary.com and go here thechive.com/2010/08/10/girl-quits-her-job-on-dry-erase-board-emails-entire-office-33-photos/"
2 "20 hours a wk on farmville haha"