1 definition by AzFLYINGzFRIDGE

Top Definition
Major Down Syndrome, when some one is very retarded.
My good friend raged on xbox live and punched his mum... something only someone with MDS would do...
#mds #majorly retarded #plain retarded #special kid #downs
by AzFLYINGzFRIDGE April 20, 2011
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