a house or living situation at which you feel less likely to contract an illness from its unclean floors by keeping your socks on. Extreme cases of this are "shoes on houses" where you are sucidal to take your shoes off.
Person 1: Hey where are you going?
Person 2: Jeff's house
Person 1: Oh be sure to keep your socks on, that house sent Jimmy to the hospital last week cuz he took his socks off. Such a socks on house.
Person 2: What a dumb ass. Yeah, I'm keeping the socks on.