It's the short hand for 'one of these'.
Used when someone does a 180 on their word, contradicts themselves, or says, does or thinks something so profoundly stupid there is no other response other than wuez.
Guy 1 : Man I really hate blondes

Guy 2 : ok

a bit later

Guy 1 : wow that blonde is so cool, I don't hate them

Guy 2 : wuez?
by huntertheshunter September 23, 2021
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