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the pronouciation of the acronym STFU which means shut the fuck up. Stiffoo is just a better way of trying to say the letters, or more pg way of saying the full meaning. It also seems to lose some of its aggresion with the abbrivation.
person 1: so i was like 'blah blah blah' after she was all 'yadda yadda yadda'
person 2: god, stiffoo!

person A: stiffoo noob!
person B: why dont you just swear like a normal person?
stiffoo by anevilscientist September 22, 2007
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grande stiffo 

Slang word for erection, made popular from when the Adam Sandler played the "Opera Man" when singing about a womans chest
"Fergia Fergia
Nipple-a Niple-a Niple-a Niple-a Niple-a Niple-a Niple-a..
CANTALOPAS!! EL-PROTRUDO-O
OPERA MAN....
Grande Stiffo"
Related Words

Stiffolis 

(n.) A condition of the male reproductive organ that causes extreme pain when urinating, orgasming, or becoming erect. Caused by lack of soap on ones genitals for an extended period of time. Most often transmitted from females with infested genitals to males who are too intoxicated to make intelligent decisions. Only one cure is known, Chechnyan Deuche
Ray got his fuck on with that one bitch Reeta last night and is sure to have caught the stiffolis.
Stiffolis by Jerry Kurl November 7, 2006

Stiffocated 

When during the act of fellatio the giver chokes/struggles for breath; caused usually by either party (or both at same time) being a little too enthusiastic during their performance
Eve was so into it that she nearly stiffocated
Stiffocated by Stringer Bill April 24, 2017

stiffgoat 

"You are such a stiffgoat!"

"You Fag of Tits! Go visit stiffgoat.com!"
stiffgoat by holger2007 December 14, 2006
see STFU - homonym for STFU (shut the fuck up)
stifoo u friggin noob
stifoo by stupdworld September 10, 2003
A boner, hard-on, erection, etc. Not, however, the sixth Marx Brother.
"Jeez, even to this day that Pat Nixon sure gives me a stiffo!"
Stiffo by creedmoor December 13, 2005