Translation for the layperson: it is basically a clean version of "fuck off," sans profanity. It is unlikely that one would say this to another without a justified/specific reason to be pissed at them. Basically, one is ordering the other to not talk to them, or even come near them. Preferably get out of their sight altogether.
12 step recovery jargon referring to someone new who talks about how great life is, now that they'resober. Usually meaning that the person is out of touch with reality.
The new guy seems pretty happy for a dude who has no job, no money and no family. He must be on a pink cloud.