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typically a female that a male searches for, when all else has failed and last call has been called.

a women that you instantly know you have to double wrap your tool.
"hey its last call, lets find a skeeser and get outta here"

"lets fuck some skeesers tonight"

"that skeeser has a tight body, but her face is fucked up, im gonna do her anyway"

"dude, im wasted, im gonna nail a skeeser"
skeeser by angry irish January 9, 2007

Skeevester 

A very unattractive, creepy guy at bar, who lurks, watches, and looks for women to hit on. He is also the unattractive, creepy guy on the dance floor who will attempt to dance with you multiple times and never get the hint that you don't want to.
"Oh my god, that creepy guy keeps staring at us. What a skeevester!"

"That guy would not stop trying to dance with me. He is a total skeevester!"
Skeevester by Jackie McNasty May 20, 2009
Something you get from slutty girls named Erica
I woke up and my cock itch fucking erica gave me skeebes
A bubbly complex mass of organisms combined into a single being. Known for its hysterical laughter, blaming and world renowned "your mother" jokes.
Whos that pokemon? Its Seeses!
Seeses by Beavin the Keavin May 21, 2015
Genereally means bastard, but not in the literal term. Just an annoying person who you don't like or who has done something stupidly irritating. Most comonly known from Mean Girls.
"Oh my god, you're such a skeese"
Skeese by Ill Hubs January 17, 2010
A group of bitch's who scheme on other people relations, either trying to break them up or steal a partner
Those skeezes are always scheming
Skeezes by Imadef March 4, 2009