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Refers to being so busy that you don't have time to use a restroom.

Used in the context of passing someone who wants to chat and you do not have time.
Cher: I swear, ever since I had Sonny axed, it's been non-stop busy for me.

Sting: Bloody hell! Know what you mean. Ive been running so much this week, I have to shit standing up!
by Richard Halliburton, Jr. December 01, 2007
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