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To be without testicles.

Pronounced "Sans TESTI-CLEES", emphasis on the final syllable.

First known use was Episode 41 of Family Guy, "Screwed the Pooch", released in 2001.
If Nick isn't going to shut the fuck up, he better start applying for a new passport - because his new name will be "Sans Testicles"

From Family Guy:

Mr. Putersmith: You know Brian, this is a lot like a greek tragedy. Of course you'll be playing the role of Sans testicles.
by TheMicroMoth October 05, 2016
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