Mudhead is a racial epithet used in the Milky-way galaxy that refers to the humanoid race of 'Mankind' that inhabits the planet Earth. Since Earth resides so closely to its sun and the evolution of life is so destructive, Earth is regarded by the intelligent races of the galaxy as a filthy and inferior world. The term is generally used to describe Mankind's self consuming fear of existence, and his primitive rationalization process. It also describes Mankind's inability to focus for prolonged periods of time (relative to him, or anyone else)
"He could never understand what we say, he's a mudhead."
"It's almost funny to just sit back and watch the mudhead suffer."
Guido 1: Bobby "mushead" Martino was just sent to jail.
Guido 2: Gee, I should get in contact with him again.
Guido 1: What the fuck are you saying! Ahhh. He was just sent to jail. You asshole, you're duh real mushead!
Singer for Cuphead: "Well, Cuphead and his pal Mugman, They liked to-"
Triggered Smartass: "They swapped places. Its Cupman and his pal Mughead."
Singer for Cuphead: "._. Boi"
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.