Moofaffalo Share definition Flag A woman that looks like a cross between a cow and buffalo. Usually large and slobby looking with low iq Guy1-u going to pick that shela up for date? Guy2- na she looks like a moofaffalo mate Moofaffalo by Thriller driller July 22, 2015 0 0 Get merch Get the Moofaffalo mug. Buy Now — $32.95 See more merch