The main man behind the greatest band ever 'Dire Straits'. Arguably one the greatest guitarists ever.
by mairs May 24, 2006
The Mark Knopfler syndrome is, in musical circles, an occurrence when a musician is incredibly skinny and homely eventhough he is well off.

It references Dire Straits' frontman, because he was unbelievably skinny and homely, eventhough he was well off.
Joe over there must have Mark Knopfler syndrome. He is so skinny, yet his band is making it big.
by George Felix February 9, 2015