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Giving a shit; caring about something. Generally used in sarcasm, though sometimes give-a-shititis is used with a preceding negator, such as doesn't-give-a-shititis, or I-don't-give-a-shititis.

Related to give-a-fuck bay, I don't give a shit, and so on.
Wow, after hearing you pour out your heart, I really want to help. You've given me a total case of give-a-shititis for retarded ugly children.
by medic007 June 16, 2008
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