ZooPuff Share definition Flag ZooPuff - Originated in Cincinnati, Ohio by two boys standing in line at Kings Island. The term was originally made as a racial slur towards blacks, but is now used to rep. what ever the user sees fit. LOL! Look at that Fu**ing ZooPuff.Yeah, you're lame ZooPuff.Suck my ZooPuff.Your mom is a ZooPuff. ZooPuff by Neron05 November 15, 2009 0 0 Get merch