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Someone under the influence/ high on meth who looks or is acting weird or strange in behavior(s).
Look here tweerdo, you're creeping me out. Sit your ass down over there and don't move.

Look over there, she looks like a tweerdo. Typical in the Independence walmart aisles.
tweerdo by SavagebeautyTK November 25, 2018
Related Words
Tired, Wired and Weird. Usually a state of being after a significant period of partying.
We are going to be hella tweird after this weekend.
Tweird by myco2012 October 8, 2011
something that is tite and weird
Damn dawg, that shit is tweird!
tweird by liljayhawkboyy May 19, 2008
Too weird
You're tweird.
Tweird by Fullsaile February 21, 2017
A kid 11 to 12 years old who is not quite a teenager who we refer to as a "TWEEN" (meaning in between child and teen). They are starting puberty which makes them "WEIRD". Thus they are a TWEIRD!
OMG my daughter is always talking about boys and she is so spacey lately. What am I going to do, she is such a tweird?!
Tweird by BabyChaun September 14, 2011
That was weird.
Tweird man!
tweird by Natarooski January 24, 2013