Top definition
When a man or woman who works as (but is not limited to) a truck driver and when they arrive home they do not stop talking nomatter what you do they cut you off at every chance to continue talking about something that only really matters to them in the first place.
Guy 1- Dude my dad cam home last night and never stopped talking for 5 straight hours!

Guy 2- Sounds like a serious case of truck driver disease to me man.
by HeyYouInTheBushes! March 17, 2010
Get the mug
Get a Truck Driver Disease mug for your barber Callisto.