A description of those Hollywood-type women who have had so much botox and "work" done it is impossible to determine their true age. They could be anywhere between 30 and 60 - thixty
Q:How old do you think Sharon Stone / Madonna / Cher / Demi Moore / Joan Collins, etc is?
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.