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Sethko is the combination of Seth and Nieko. Seth is the story character from the Twilight series Eclipse, and Nieko (Nieko Hayer) is the aspiring actor who many fans demand get the acting part of Seth Clearwater.
Chatroom:

BlueSphere: Hi There.

Muffic_Sethko: Yo.

RMS_Sethko: Hey!.

Twi05TeamSethko: WAZUP

BlueSphere: What the hell is with your user names?

RMS_Sethko: What's up with YOUR user name.

Twi05TeamSethko: Seriously, noob!

Muffic_Sethko: Only fags don't know what Sethko is.
Sethko by BananaNutMuffic July 16, 2009

sethjoziah

One of the most knowledgeable people on video games you will ever meet
Yo, screw Wikipedia, Sethjoziah knows games frame by frame
sethjoziah by SteepSlope June 25, 2017
Related Words
When you say you will make out with a girl but wouldnt date her. That is a Sethod of life right there
Seth- Id make out with that chick but i would never date her.

Girl- You follow the sethod of life dont you?
sethod by sethodsoflife December 20, 2013

sethhole 

When ketemine is injested, a "sethhole" is when you are stuck and you can't move and a big sweaty guy humps you.
At that rave I was caught in a sethhole
sethhole by Rev WJ October 8, 2005

sethkasketch 

a roamer of the internet, who is made of 56% Win, 33% Epic, 10% awesome and 1% lolcat
he wins even when he loses and hates many MMO's. everyone loves him just for being sethkasketch.
Zezima: OMG that kid is sethkasketch! i r so honored.

Sethkasketch: get off me noob.
sethkasketch by sethkasketch December 26, 2008
noun
- the science of animalistic seth behavior.
- the study of the human seth; behavior and social organization from a psychological perspective.
Most quotes fashioned after sethology are unnecessary, unexpected, and unwarranted- save yourself for it is ridiculous and may cause harm to the point of uncertainty of being.
Sethology by wustang October 21, 2014

Sethmoore 

Sethmoore is a retarded persons name most people called Sethmoore are disabled or have learning disabilities Sethmoore means gay and Sethmoore likes to shove used dildos up his ass
Sethmoore likes gay anal and blowjobs
Sethmoore by Sexytruth6969 October 23, 2019