Top definition
(verb) To be extraordinarily courageous in the face of extreme pain and even risk of life. To power on beyond the comprehension of mere human beings.

A more courageous version of man up.
The pain from the Man o' War stings was unbearable and paralysis from the toxins was setting in, but she made herself Nyad-Up and swam 82 nautical miles across the Florida Straits.
by FlKeysKevin September 29, 2011
Get the mug
Get a Nyad-Up mug for your cousin Larisa.