A place located in such an obscenely obscure part of the world that one would rather fuck his/her own sister/brother than to even fathom venturing to it for any reason. At all. Ever.
Ted: Hey man, can you take me home?
Bob: Sure bro, where do you live?
(Ted gives his address)
Bob: No way, man. That's in the middle-of-ass nowhere. Good luck finding someone to haul your ass all the way out there.

Carla: Oh shit, we're lost. And we're in the middle-of-ass nowhere.
Brandon: Oh God, I'd legitimately rather be fucking my own sister than sitting here.
Carla: I AM your sister, Brandon.
Brandon: ...I'll grab the condoms from the truck.
by HamStatler March 25, 2011
Get the Middle-Of-Ass Nowhere mug.