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1) Pertaining to the work of comedy writer Seth MacFarlane

2) The methodical school behind the work or any student thereof

3) A general reference to a humoric style which favors cut-aways, overdrawn bits and Reagan-era cultural references
1) Carly: Wow, Fox is really on a MacFarlanian craze these days. They just picked up three more of his sitcoms.

2) Braxton: Did you know Temple is offering a course in MacFarlanian psychology in the fall? I'm so there.

3) Jamarr: Yeah, the trick is to be utterly MacFarlanian in the commitment to the gag.
by baroquegangsta April 15, 2008
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