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A Leper Supreme is the act of having sex with a leper (one who has leprosy) through new orifices, created by mashing soft, rotten parts of their skin with your penis. After banging several new glory holes into your unfortunate friend, one finishes the Leper Supreme by dipping a nacho chip into a gooey part of their head and eating it.
"Call Gary over, its time for a Leper Supreme."

"Oh lawd, Kerpal sure does love Leper Supremes!"
by TheBigfilthy April 30, 2009
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