A trade where the person who is being asked gets ripped off at a major level. When an Isaac Trade is asked, everyone is left wondering how stupid the person who is asking to trade is for asking such a stupid or unfair trade. Usually occurs with food or during lunchtime, but may occur elsewhere.
Hey dude, want to trade that box of oreos for this half eaten saltine cracker? No man! That's an Isaac trade you idiot!
by RocketPenguin October 26, 2013