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Hoe-Fo-Sho = Hoe For Sure
A girl thats very obvious or notorious of being a hoe or slut
used in the movie 40 Year Old Virgin
Dude that bitch is a hoefosho!!

She was a Hoe, fo sho!
by Wuthaphuq November 02, 2009
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A female that is undeniably slutty, from the way she walks to the way she dresses. There are no doubts about her.
- "Hey Melvin, did you bang Jaunita last night?"

- "Damn straight nigga, she's a hoe fo sho."

by Melvin_Lover July 27, 2006
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