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Acronym for Fuck You, Facebook. Used when one of the myriad of annoying quirks that Facebook routinely exhibits is frustrating the ever-loving shit out of you.
Facebook changed their layout again? FUFB!
by ESTO Weez July 16, 2010
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2
Fuck you frat boy

A derogatory term aimed at losers who buy friendships and thrive on cheating in college and raping young ladies.
Frat Boy: "Ladies come to our party tonight"
Ladies: "F.U.F.B."
by Coliebear March 30, 2008
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