A serious condition in which a male may begin to feel strong sexual attraction to unattractive females after a long period of sexual inactivity. The condition can be alleviated through the use of masturbation, but this will only help for 2-3 hours, 2-3 times per day.
Having not had sex since March 8th, 2006, Johnny developed Desperate Dick Syndrome and began lusting after fat girls.
by Collin Jones October 02, 2007
Get the Desperate Dick Syndromemug.