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DERPLEXIA 

~Currently Proposed as a New Addition to the DSM (Diagnostic and Statistical Manual of Mental Disorders) and Under Review~

DERPLEXIA: the condition or state of extreme brain pain and mind melts that occur due to any number of interactions with or knowledge of herp-a-derp type individuals.

Clincal indications of a state of Derplexia are commonly reported by individuals as including:

1. cognitive processes along the lines of "what the fuck" or "seriously?", which often coincide with

2. physiological changes as commonly seen in persons experiencing anger or rage, and

3. behavioral manifestations such as placing one's palm to forehead (facepalming), discontinuation of prior activities (so as to give their full attention to attempting to process and assimilate new info), or other indicators of disbelief and perplexity of thought.

Research to date is still in preliminary stages, thus therapeautic interventions are quite limited. Currently, the only effective treatment known is full or partial extermination of either the herp-a-derp type of individual or the suffer's own life, and a full discontinuation of all herp-a-derp topics in conversation.
Person 1: <<insert some random reference to a herp-a-derp person or celebrity>>

Person 2: <<awkward pause of silence/looks of disgust>>
"Ugh, I hate when you tell me these weird stories. I always don't feel so well afterwards. And now my head hurts... thanks buddy..."

Person 1:
"Oops. I hope you don't have Derplexia! That stuff is serious!"
DERPLEXIA by Meow Mixerology May 21, 2012
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derpleganger 

Derprah (Derpin' Oprah) would be Oprah's derpleganger.
derpleganger by miknight December 9, 2012
Related Words

Deuslexia 

Not being able to form a full sentence while also mispronouncing most of the words :D
Jesus u can't even say that right are u deuslexic or smth?? - Deuslexia -

Dewplexism 

Dewplexism: when someone has a speaking disorder and sounds like their crying
damn that kid playing minecraft sounds like he has a serious case of dewplexism
Dewplexism by ilikekohipvp June 22, 2016

derpreciate 

When something lessens in price or estimated value as a result of an act of stupidity, or derp.
The population of the UK voted for Brexit and now the British pound has been derpreciated.
derpreciate by Danack June 7, 2018

derpleganger 

The owner of an email address that's only a character or two different to yours who constantly gives your email address to his contacts.
My derpleganger gave my email address to his tax auditor. AGAIN!
derpleganger by krimhorn March 10, 2014

dexlexia 

A Individual that doesn't care what you say. They hear you but don't care bc and continue on with what they were saying. Leaving you confused.
Girl-Are you dexlexia
Friend-so your good
dexlexia by Slim C.U TLS November 26, 2016