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A college of the University of Minnesota-Twin Cities which is the only university branch worth attending. Contrasted with the Carlson School of Management and the College of Liberal Arts, the College of Science and Engineering (CSE) is populated by people who don't deserve to be kicked in the balls (Carlson students do; CLA students have none to be kicked). Most CSE students could kick your ass in any academic endeavor, and they'd be willing to prove it.
Carlson student: "I see by your intact testicles that you attend the College of Science and Engineering!"

CSE student: "Why thank you, Carlson student! Now stand still with your feet four feet apart."
by WaspHives July 03, 2010
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