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When a member of a band, particularly a vocalist or frontman has the tendency to leave and join bands several times. Sort of like a disease.
Chris Cornell left Soundgarden for a solo career, then joined Audioslave, left them for another solo career.

once the infection starts, it's hard to stop, and you'll be left to aimlessly join bands, and leave intermittently for no apparent reason.

Bassist: Dude our singer just quit!
Drummer: Man, what do we do now?
Guitarist: Screw him, he's got Chris Cornell Syndrome, he's been in like 50 bands.
Bassist and Drummer: Gross, who does that?
by Lordofpoo April 22, 2011
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