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Def 1. A tribe of Native Americans that settled in Southwest Florida. No living Calusa survive today.

Def 2. A micronation founded in 2003 in Southwest Florida. Known for its lax policies towards extradition and endangered species.
A: Did you hear what happened to Dave's girlfriend?
B: No, what happened?
A: She went Calusa on him?
B: What does that mean?
A: She disappeared
by Monksrq October 01, 2016
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