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When an individual, group of individuals, a thing, or an event epically destroys the good vibe, buzz, or high of every participating member of a large party. A massive multiple killjoy. Often is induced by the police, people that can't handle their substances, party crashers, and Justin Bieber.
"We were having the most outrageous party, but then the cops showed up and it was just a major buzz genocide, man."

"Drew's party was the craziest shit since Spring Break '98, but then some asshole started playing Justin Bieber!"
by Drew182 October 21, 2011
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