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noun. A disease attributed to many anime side characters that are initially introduced as interesting, powerful, or popular characters that get incredibly nerfed by the plot to make the main protagonist look better by comparison.
Rock Lee and Neji used to be dope characters before they all caught Anime Side-Character Syndrome (ASS) in Naruto Shippuden.
via giphy
by ChidoriSnake September 04, 2019
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