The 50 AE cartridge is one of the most powerful handgun cartridges today. It was designed for use in the desert eagle pistol by magnum research in the early 90's and is still one of the most sought after calibers for the desert eagle. A 300 grain 50AE bullet shot out of a desert eagle with a 6 inch barrel will travel at around 1400 feet per second. Compare that to your every day .45acp that shoots a 230 grain bullet at 800 feet per second. or a 500 smith and wesson magnum revolver that will shoot bullets larger than a 50AE at almost 1900 feet per second. While the 50AE isn't the largest, most powerful handgun around, it is still a monster. The 50AE cartridge isn't just an exclusive round for the desert eagle, either. Other firearms that chamber this cartridge are:

AMT AutoMag V, LAR Grizzly Win Mag, Freedom Arms model 555, Magnum Research BFR.
I'm taking my 50 AE to the shooting range and i'm not coming home until my wrist hurts!
by MasterJeem January 19, 2009
As in most big bore weapons, the 50 AE is designed for more experienced shooters. With more power than the popular .44 magnum, you have to sacrafice the amount of ammunition in the magazine. 7+1. And for people who think its overkill to own a Desert Eagle chambered in this caliber, then just dont buy it. I hear of claims that it will generate too much penetration for self defense, and that it has no good purpose, but those that make these claims obviously have had either a bad experience while shooting one, or just too cheap to fork out the money for the ammo. but i also hear that a .357 mag will go through an engine block. i am still yet to see it. i doubt it will. thats a myth. so i say to those who down talk this great cartridge, bring your .357 and we'll see what round stops what first. I own a Mark XIX chambered in .50 and cant seem to find anything wich would deter me from using it in such a manner. its a good hunting round, and i shall use it for self defense, and carry it on a daily basis. the weight comes with the territory. Most people that shoot these for the first time usually tend to limp wrist the weapon and cause it to jam. they also tend to push up on the magazine wich in turn will cause it to jam. as far as calling it overkill, well thats rediculious. now shooting an assailant with a .50 bmg would be overkill. after all, its a pistol. and those that wish to disagree, then just dont buy it. after all, it serves its purpose respectivley, as do most firearms.
by Deep South Shootin August 4, 2009
Big bad ass looking pistol made in Israel, you can get a .357, .40, .44, .45, or .50 AE.
This gun is one of the most powerful handguns.
A .50 AE Desert Eagle can shoot your head CLEAN off your shoulders, don't wanna mess with anyone that has one.
by Max Killian May 12, 2006