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de novo

starting from the beginning; anew
most of the malignant melanoma cases develop itself de novo from healthy skin
by YazanKoz May 21, 2016
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De whey

A meme (millennial joke) Involving a small red knuckles from the popular game franchise sonic in another virtual reality game “vr chat”. The knuckles will ask “do you know de whey” in a deep Ugandan accent.
by Archie Morrison February 16, 2018
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de-goonification

To remove any display or hint of goon like behaviour from ones sight, life, social network site etc
If you ever think after you've posted something on facebook "hmmm that was a bit goonish of me" then you need be worried about being involved in de-goonification.
I was looking through my news feed and some people's statuses have really made me consider starting a de-goonification process on my page
by Goonette23 March 13, 2011
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De-truff

To unzip and remove the lower part of a pair of cargo-trousers or cargo-pants when weather or current activities make it appropriate to do so. (See truff)
The sun has come out! Time to de-truff!
by carlbtv October 12, 2011
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Fresh DE

"Marvel at the stunning and captivating "Fresh DE" - a creature of such exquisite grace and charm that he bears an uncanny resemblance to the inimitable Drake, complete with a coiffure of legendary Fboy proportions. But beware, for within his soul lies a wound of the gravest sort - the haunting PTSD brought on by the mere sight of a line of code, inflicted upon him by the unforgiving realm of programming. Such is the price of greatness, for his powers of observation are of such prodigious might that the very act of his "lightskin stare" is enough to render lesser beings speechless with admiration. Let it be known that to besmirch this paragon of magnificence is to invite a fury of such wrathful intensity that even the gods themselves would tremble in fear, for he is a being of pure elegance and a force of nature unto himself."
"Is that a plane? Is that a bird? No it's Fresh DE with the lightskin stare!"
*Chrishan - Sin City plays*
by A certain Ed February 28, 2023
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De-dicked

When you RIP a mans dick off for pleasure. See "Alpha Blue"...
Dude, what did you do?
He said I had nice eyes, so I de-dicked him. He should have told me i had nice tits....
by 808-pride December 2, 2018
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de-squared

“I was de-squared by hayden
by cheekylittlerat101 February 23, 2019
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