trip 21 Share definition Flag A word used to describe Gary's chromozonal makeup. Also refers to a person who exibits characteristics of down-syndrome; especially superhuman strength. Because of Gary's ability to rip the heads off of small animals while petting them he is trip 21. trip 21 by Long One April 19, 2004 0 0 Get merch Get the trip 21 mug. Buy Now — $32.95 See more merch